【摘要】 采用猴头菇、香菇、茯苓 3种真菌的多糖等比混合作为总多糖 ,再按一定比例配以葡萄籽多酚和甘草酸 ,制成复合真菌多糖 ,观察其抗肿瘤作用效果以及对荷瘤鼠免疫功能的调节作用。实验以 10 0、2 0 0、40 0 mg/ kg BW3个剂量 (复合多糖 、 、 组 )给小鼠灌胃 3周后右前腋下接种 S- 180 ,继续灌胃 10日后实验。同时设 2 0 0 m g/ kg BW的香菇多糖对照组和荷瘤模型对照组 ,另设正常对照组。结果显示 :该复合多糖具有明显的抗肿瘤作用 ,3个剂量组的抑瘤率分别为 37.74%、44 .73%、48.32 % ,同等剂量的复合多糖 组的抑瘤效果明显优于单味香菇多糖。荷瘤鼠 L3T4百分率和 L3T4/ L yt- 2比值明显下降 ,NK细胞活性、IL - 2、IFN-γ的诱生水平显著低于正常小鼠。复合多糖作为免疫增强剂 ,可明显提高荷瘤鼠 L3T4百分率和 L3T4/ L yt- 2 ,对 L yt-2的百分率也有一定的提高作用 ,增强 NK细胞活性 ,促进 IL - 2、IFN-γ的诱生水平。单味香菇多糖也有一定改善荷瘤鼠免疫功能的作用 ,但是不如等剂量复合多糖的效果明显 ,佐证不同来源的抗肿瘤作用有效成分的相互配伍、相互协同的重要性。更多还原

【Abstract】 Fungus polysaccharides compounds (FPC) are the mixture of procyanidins oligomers,glycyrrhetinicacid and polysaccharides of hericium erinaceus,lentinus edodes and poria cocos. The antitumor effects of FPC and its immunity regulating effects as an immunostimulant on the mice burdened with sarcoma 180 (S\|180) were studied.FPC (100,200 and 400mg/kg BW) was gavaged to mice for 31 days. S\|180 was transplanted to these mice on the 21th day. Lentinus edodes group was gavaged 200mg/kg BW saccharine of lentinus edodes. The results showed that FPC could inhibit the growth of S\|180 effectively.The inhibitory rates were 37 74%,44 73% and 48 32% respectively. The antineoplastic activity of FPC (200mg/kg.BW) was more effective than polysaccharide of lentinus edodes at the same dose. In S\|180 burdened mice,the percentage of L 3T 4 and the ratio of L 3T 4/Lyt\|2, NK activity and the induced IL\|2, IFN\|γ levels were decreased significantly compared with the normal control group. As an immunostimulant, FPC could increase the percentage of L 3T 4 and the ratio of L 3T 4/Lyt\|2 in S\|180 burdened mice, but had no significant effects on the percentage of Lyt\|2. Polysaccharide of lentinus edodes alone could also increase the immunity competence of mice burdened with S\|180, but was not better than that of FPC at the same dose. It could be concluded that the compound of antineoplastic component could be synergetic.更多还原