【摘要】 目的探讨血清可溶性细胞间粘附分子－１（ｓＩＣＡＭ－１）和转化生长因子β_１（ＩＣＦ－β_１）与肝纤维化及肝损害的关系。方法采用酶联免疫吸附法（ＥＬＩＳＡ）检测正常人、慢性肝炎、肝硬变患者血清ｓＩＣＡＭ－１、ＴＧＦ－β_１。结果慢性肝病患者各组血清ｓＩＣＡＭ－１、ＴＧＦ－β_１均显著高于正常人，各组间存在显著性差异。两者与透明质酸（ＨＡ）呈正相关，与血清草酰乙酸转氨酶（ＡＳＴ）、总胆红素（ＴＢｉｌ）、球蛋白（Ｇ）呈显著正相关；与血清白蛋白（Ａ）呈显著负相关。结论慢性肝病患者血清ｓＩＣＡＭ－１和ＴＧＦ－β_１可以作为判断肝纤维化及肝损伤程度的指标。更多还原

【Abstract】 Aim To study the relationship between serum levels of soluble intercellular adhesion molecule-1 (sICAM-1), transforming growth factor- (TGF- ) and hepatic fibrosis, liver damage in patients with chronic liver disease. Method Serum levels of sICAM-1 and TGF- were measured by ELISA in 138 patients with chronic liver diseases and 20 healthy person respectively. Results Serum levels of sICAM-1 and TGF- in patients with chronic liver disease were significantly increased compared with healthy person. The serum levels of sICAM-1 and TGF- in different stages gradually increase with the progression of liver damage. TGF- and sICAM-1 were correlated positively with serum HA and correlated significantly positively with serum levels of AST, tolal bilirubin, globulin. Markedly negative correlation among sICAM-1, TGF and serum albumin were found. Conclusion Serum levels of sICAM-1 and TGF- are two serum markers for detection of liver fibrosis and damage更多还原