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^186,188Re-SZ39的药学性能研究

Study on the Pharmacal of^186,188Re-SZ39

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【Author】 Zu Jian hua 1,WU Yuan fang 1,DONG Mo 1,LI Hui yuan 1,ZHANG Yu long 1, LAN Qing 2 [WT5”BX][ST5”BZ](1.Shanghai Institute of Nuclear Research,the Chinese Academy of Sciences, Shanghai 201800,China; 2.Brain Surgery of the Second Hospital Affiliated to Suzhou Medical College, Suzhou 215007,China)

【机构】中科院上海原子核研究所放药中心标记部!上海201800；苏州医学院附二院脑外科!江苏苏州215007；

【摘要】本工作对单克隆抗体 MAb- SZ39的铼标记物进行动物体内稳定性、免疫活性、细胞杀伤能力及对荷人脑胶质瘤裸鼠的抑制率等测试。结果表明标记物细胞杀伤能力强 ,体内较稳定 ,且能明显抑制肿瘤的生长 ,作为一种免疫治疗剂具有良好的应用前景。更多还原

【Abstract】 The stability,immunocompetence and cytotoxicity in tumor as well as tumor inhibiting rate of 186,188 Re SZ39 are investigated. The results indicate that 186,188 Re SZ39 is stable in vivo by imaging and the volume of tumor of nude mice reduced obviously. So 186,188 Re SZ39 has a strong cytotoxicity effect against glioma cells and is of good prospect as immunoradiotherapeutic agent.更多还原