【摘要】 目的:利用Wistar大鼠实验探讨补充L-Arg对机体免疫功能的影响。方法:观察补充L-Arg对体液免疫、细胞免疫功能,血、尿NOx~-水平以及脾脏形态学的影响,以及L-Arg对免疫抑制状态的调节作用。结果:一定剂量的L-Arg能够增强B细胞介导的体液免疫功能;对于体外培养的具有亲代B细胞活性的小鼠杂交瘤细胞株分泌功能无促进作用;不影响正常小鼠的T淋巴细胞转化功能;增强T细胞介导的Ⅳ型超敏反应;促进脾脏的免疫功能和淋巴小结增生;增加体内NO产生但不会造成NO及其代谢产物的蓄积。结论:补充一定剂量的L-Arg具有免疫增强作用。更多还原

【Abstract】 Objective:To explore the influence of L-arginine supplement on immune function of rats and mice. Methods:To observe the change of humoral and cell immune response, the level of nitric oxide content in blood and urine,and the spleen morphology influenced by L-arginine supplement. Results: A certain dose of L-arginine could increase antibody production by B-cell mediated humoral immune response, intensify delayed hypersensitivity, and promote immune function of spleen and hyper-plasia of lymph nodule. It didn’t influence T-lymphocyte transform function in normal mice.There was no promoting function in the secretion of hybridoma in vitro with certain dose. L-arginine can increase the production of nitric oxide without storage in the body. Conclusion:L-arginine supplement can enhance the body immune function.更多还原