【摘要】 目的:研究血液灌流与动脉化疗栓塞(TACE)联合应用治疗肝癌的疗效。方法:(1)对象:灌流组17例肝癌患者,采用TACE联合NK-107树脂血液灌流进行治疗。对照组11例肝癌患者,采用单纯TACE治疗。(2)观察项目:阿霉素血药浓度、临床症状体征的变化、血常规、心肌酶、肝肾功能、心电图、超声、CT、甲胎蛋白等。结果:灌流组的阿霉素给药剂量虽然为对照组的1.5倍,但血药浓度低于对照组,于第3、14天时降低程度具有统计学意义。血象、心肌酶、肝肾功能与给药前比较均无明显改变。临床表现:灌流组在发热、胃肠道反应、脱发、心脏副作用等方面均较对照组为低。结论:血液灌流配合TACE可以较好吸附逸出至肝外化疗药物,有效降低毒副作用,可提高患者对介入治疗的耐受性。更多还原

【Abstract】 Objective:To study the effects of the combination method of hemoperfusion and transcatheter arterial chemo-emboliza-tion (TACE) on patients with hepatocellularcarcinoma (HCC). Methods:Seventeen patients with HCC in perfusion group accepted the combined treatment of TACE and NK-107 resin hemoperfusion, while 11 patients with HCC in control groupwere treated with TACE only. The observation items included blood concentration of doxorubicin, clinical performance(signs and symptoms),blood routine,myocardial enzyme, function of both liver and kidney, ECG, ESG, CT and AFP. Re-sults: Although the drug dosage in perfusion group was 1.5 times that in control group, the blood concentration of doxorubi-cin in perfusion group was lower than that in control group on the 3rd and 14th days after treatment. Compared with pre-treatment, there was no change of hemogram,myocardial enzyme and function of both liver and kidney. The clinical perfor-mances in perfusion group were slighter than those in control group, such as fever,gastroenteric response, hair loss and side-effect to heart. Conclusion: TACE combined with hemoperfusion can successfully absorb the chemotherapy drugs escaped from liver and effectively alleviate the toxicity adverse effect of interventional therapy,and then enhance the patient’ toler-ance to anti-cancer treatment.更多还原