【摘要】 目的　探讨Fas及bcl 2在视网膜母细胞瘤的表达及意义。方法　用免疫组织化学SP方法检测了 45例视网膜母细胞瘤及 12例正常视网膜组织中Fas及bcl 2蛋白的表达 ,并进行比较。结果　Fas在视网膜母细胞瘤组织及正常视网膜组织的表达分别为 0 .2 5 5± 0 .441,0 .0 83± 0 .2 89,两者比较差异无显著性 (P =0 .114 8) ,均呈低表达 ;bcl 2在视网膜母细胞瘤中的表达为2 .70 2± 1.0 82 ,与正常视网膜组织中 0 .16 7± 0 .389相比差异具非常显著性 (P <0 .0 0 0 1)。结论　Fas在视网膜母细胞瘤及正常视网膜中均呈低表达 ;而bcl 2在视网膜母细胞瘤中呈明显高表达 ,其可明显抑制凋亡的发生 ,与肿瘤的发展关系密切。更多还原

【Abstract】 Objective To investigate the significant of Fas and bcl?2 expression in retinoblastoma.Methods The immunohistochemical staining was performed to detect Fas and bcl?2 in 45 cases of retinoblastoma and 12 cases of normal retina.Results The expression of Fas in retinoblastoma and normal retina were 0.255±0.441 and 0.083±0.289 respectively ( P =0.114?8).bcl?2 was high in retinoblastoma 2.702± 1.082 and low in normal retina 0.167±0.389,showing significant difference( P <0.000?1).Conclusion Low regulation of Fas expression in retinoblastoma and normal retina suggested that it is a throughout event which prohibit the apoptosis. The high expression of bcl?2 in retinoblastoma was close associated with the tumour development.更多还原