【摘要】 昆明种小鼠灌胃以螺旋藻多糖 (PSP) 10 0 m g/ kg,2 0 0 mg/ kg,连续 10 d。结果发现其对正常小鼠血糖无明显影响 ,而相同剂量的 PSP对链脲佐菌素性糖尿病小鼠高血糖有明显的降低作用 ,与糖尿病模型对照组相比 ,PSP10 0mg/ kg,2 0 0 m g/ kg的血糖降低率分别为 2 3.6 %与 30 .1% ,差异非常显著。另外 ,相同剂量的 PSP还可显著对抗肾上腺素及葡萄糖所致小鼠血糖升高 ,表明 PSP可拮抗肾上腺素刺激肝糖原分解作用及抑制葡萄糖在小鼠肠道的吸收。上述结果提示 PSP具有一定的降血糖活性 ,值得进一步深入研究更多还原

【Abstract】 With the dose of 100 mg/kg, 200 mg/kg by ig administration to normal and streptozotocine induced diabetic mice for 10 days, it was found that PSP had no significant hypoglycemic effect on normal mice, however, it could remarkably decrease the blood glucose in streptozotocine induced diabetic mice. Compared with the diabetic model mice, PSP 100 mg/kg, 200 mg/kg could decrease the content of the blood glucose by 29.1% and 30.1% respectively. In addition, with the same dose by ig administration, PSP could decrease the hyperglycemia that was induced by intraperitoneal adrenaline and by ig glucose in mice. Such a result showed that PSP may antagonize the glycogenolysis which is stimulated by adrenaline in liver and inhibit the absorption of glucose in intestinal in the mice. The above results suggested that PSP posses certain hypoglycemic effect and deserve to further studying.更多还原