【摘要】 目的　评价长春地辛对 NSCL C的疗效 ,并观察其在临床应用中的毒副作用。评价长春地辛与 CAP方案联合应用是否有协同作用。方法　 6 1例 b期或 期的 NSCL C病人被随机分成两组 :31例病人给 CAP+长春地辛方案治疗 ,30例病人给 CAP方案治疗。两组病人在性别、年龄、一般状况评分、分期、组织学及既往接受化疗各方面具有可比性。结果　 CAP+长春地辛组有效率为 41.9%明显高于 CAP组的 16 .7% (P<0 .0 5 )。长春地辛的主要毒副作用为骨髓抑制、轻度周围神经毒性和静脉炎。CAP+长春地辛方案的剂量限制性毒性为骨髓抑制。结论　国产长春地辛对 NSCL C疗效肯定 ,长春地辛与 CAP方案联合治疗 NSCL C具有协同作用 ,取得良好的疗效。毒副作用可以耐受。更多还原

【Abstract】 Objective To evaluate the efficacy of VDS in NSCLC patients and to observe the side effects of VDS.Methods Sixty one patients with advanced NSCLC (stage Ⅲb or Ⅳ) were divided into 2 groups randomly to give CAP+VDS (31 cases) or CAP (30 cases) regimens.The characteristics were well balanced between the 2 groups with regards to sex,age,performance status,stage,histology and previous treatment with chemotherapy.Results The response rate (41.9%) in the CAP+VDS group was higher than that (16.7%) in CAP group ( P <0.05).The main side effects of VDS were myelosuppression,peripheral neuropathy and mild phlebitis.The dose limiting toxicity of CAP+VDS regimen was myelosuppression.Conclusion The efficacy of VDS to NSCLC was confirmed.There was some synergy when VDS was combined with CAP regimen.The side effects were tolerable.更多还原