【摘要】 对复合真菌多糖作为保健食品的抑癌作用进行评价，并初步研究其作用机制。［方法］选用小鼠Ｓ_１８０肉瘤及Ｌｅｗｉｓ肺癌移植性肿瘤模型，以《保健食品功能学评价程序和检验方法》为实验依据。［结果］复合真菌多糖０．３３ ｇ／ｋｇ、１．００ ｇ／ｋｇ剂量组对小鼠移植性Ｓ_１８０肉瘤及Ｌｅｗｉｓ肺癌抑制率两次均达到３０％以上．复合真菌多糖０． ３３ ｇ／ｋｇ组可显著增加小鼠腹腔巨噬细胞吞噬鸡红细胞的吞噬率，１． ００ ｇ／ｋｇ组对小鼠 ＮＫ细胞活性也有明显增强作用人［结论］复合真菌多糖对小鼠 Ｓ_１８０肉瘤及 Ｌｅｗｉｓ肺癌有明显的抑癌效应，其机制可能与调节机体的免疫功能，提高机体的免疫监视作用有关。更多还原

【Abstract】 To evaluate the antineoplastic effect on compound fungal polysaccharide （OFP） as health food and study its principle. [Methods ] According to （Procedures and methods of function evaluation for health food） of health ministry, select the mice bearing transplanted cancer of S₁80, sarcoma and Lewis lung cancer as animal models. [Result ] The inhibitory rate of mice transplanted S₁80 sarcoma and Lewis lung cancer in CFD 0. 33 g/ kg and 1. 00/kg. Bw Group were both above 30% for twice. The CFP 0. 33 g/kg BW and l/00 g/kg BW group could in crease the phagocytic activities of perltoneal macrophanges to chicken RBC and foe activities of NK cells of mice respectively. [Conclusion ] The CFP has a distinct antineoplastic effect on mice transplanted S₁80, sarcoma and Lewis lung cancer, the mechanism may have relationship with its regulating the immunologic function and Improving the immunosurveillance of mice.更多还原