【摘要】 [目的 ]　探讨湖区血吸虫病中度流行不同化疗策略的效果和费用。 [方法 ]　采用整群抽样于 1997～1999年 ,选择洞庭湖沿岸一线疫情基本一致的 12个自然村进行观察 ,居民感染率均在 10 %到 15 %之间。 6个村为询检确定化疗对象 ,每年对 6～ 60岁人群筛选一次 ;6个村为IHA试验确定化疗对象 ,每年筛选一半人群。 [结果 ]　在两年化疗期内 ,询检组和IHA组化疗覆盖率分别为 47 5 %、3 9 2 %和 2 2 7%、2 2 4%。居民粪检阳性率分别由化疗前 1997年 12 5 %和 11 2 %下降到 1999年的 5 8%和 5 9%。IHA组各项费用均只有询检组的一半。 [结论 ]　在湖区血吸虫病中度流行区可采用IHA试验确定化疗对象 ,在化疗效果相近的情况下 ,较询检法节省一半以上费用。更多还原

【Abstract】 Objective] To compare the cost-effectiveness of different chemotherapy strategies in moderately endemic area of S. japonica in lake region. [Methods] From 1997 to 1999,a total of 12 endemic villages around Dongting lake where the prevalence rate of residents was 10% to 15% were selected by clustering sampling and the Villages were divided into two groups randomly. Inquiring and physical examination methods (IPE) were carried out in six villages which the population (6～60 years old) were screeened once a year. Indirect hemagglutination assay (IHA) method were applied to another six villages which the half of population in this group were screened once a year. [Results] The chemotherapy coverage rates for two years were 47.5%, 39.2% and 22.7%,22.4% in IPE group and IHA group respectively. The stool positive rates were reduced from 12.5% and 11.2% in 1997 to 5.8% and 5.9% in 1999 in IPE group and IHA group respectively. [Conclusion] Under the situation of similar effectiveness in two groups, the IHA test maybe applied to the detection of chemotherapy targets in moderately endemic areas of Schistosomiasis which the cost of IHA group was about half of that of the IPE group.更多还原