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三油酸甘油酯对抗氨水诱发大鼠萎缩性胃炎的作用

The Effect of TL on Chronic Atrophic Gastritis Induced by Ammonia in Rats

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【作者】 曹红王敏伟甘乐凌李艳春

【Author】 Cao Hong,Wang Minwei,Gan Leling,Li Yanchun Department of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110015

【机构】 沈阳药科大学药学系!沈阳110015

【摘要】 考察了三油酸甘油酯 (TL)对长期饮用 0 0 15 %氨水所诱发的大鼠慢性萎缩性胃炎的预防及治疗作用 .结果表明 ,灌胃TL0 4及 0 8g/kg ,可使粘膜及壁细胞的损伤、胃体部及胃窦部的炎细胞浸润症状、粘膜及PAS阳性层厚度、壁细胞计数等各指标较模型组有显著改善

【Abstract】 The preventive and therapeutic effects of TL on chronic atrophic gastritis induced by ammonia were investigated.The histopathological changes were observed at the end of the experiment,the results showed that the significant increases in the thickness of mucosa、RAS(+) and parietal cell number were present in TL(0 4 or 0 8 g/kg,ig)groups after prolonged effect of 0 015% ammonia water on gastric mucosa in rats,the mucosal epithelial cell and parietal cell lesions were significantly decreased in the TL group when compared with the model group.

  • 【文献出处】 沈阳药科大学学报 ,JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY , 编辑部邮箱 ,2000年04期
  • 【分类号】R573.32
  • 【被引频次】4
  • 【下载频次】76
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