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苏子油乳剂小肠吸收动力学研究

Studies on the Absorptive Kinetics of the Perilla Oil Emulsion in Rats′ Small Intestines

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【作者】 王淑丽; 陈济民;

【Author】 Wang Shuli,Chen Jimin Department of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110015

【机构】 山东新华制药厂研究院!山东淄博张店区; 255005; 沈阳药科大学药学系!沈阳110015;

【摘要】 以测定α亚麻酸(αLNA) 含量为指标,采用大鼠在体、离体小肠吸收实验方法,对苏子油乳剂小肠吸收动力学进行了研究.实验表明:苏子油乳剂小肠吸收较好,6 小时吸收率为86 % ,胆管结扎与不结扎对吸收率无明显影响;实验浓度下苏子油乳剂在小肠上、中、下段的吸收速率常数无显著差异;其吸收机制为被动扩散.

【Abstract】 Improved intestinal absorption experiments of rats(in situ, in vitro) were used to study the absorption of the perilla oil emulsion.It was found that there was a rapid intestinal absorption for the emulsion and no marked difference of the absorptive rate between rats with and without ligated bile duct.Observation results showed that the transport mechanism of this emulsion at three concentrations was passive diffusion.There were no marked differences among the absorptive rate constants of the emulsion in the different parts of rats′ small intestines (upper,middle,lower).

  • 【文献出处】 沈阳药科大学学报 ,JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY , 编辑部邮箱 ,2000年01期
  • 【分类号】R285.5
  • 【被引频次】15
  • 【下载频次】197
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