【摘要】 目的　了解成人与儿童急性B淋巴细胞性白血病 (B -ALL)中CD34和伴系抗原表达的情况及两者是否有所不同。方法　应用流式细胞术测定了 10 8例初治成人B -ALL及 5 3例初治儿童B -ALL的免疫表型 ,并对结果进行比较分析。结果　在成人与儿童中 ,CD34+的B -ALL伴髓系抗原 (CD13或CD33)表达 (My+)的比例明显高于CD34-的B -ALL ;而两者之间无论是CD34阳性的比例还是伴系抗原表达的比例 ,均无显著差异。结论　无论是儿童还是成人My+B -ALL ,均主要来源于造血干祖细胞的恶性转化。初治儿童与成人B -ALL比较 ,它们的免疫学表型特征相似更多还原

【Abstract】 Objective To compare the difference of CD34 and lineage-associated antigen expression between previously untreated adult and childhood B cell acute lymphoblastic leukemia (B-ALL). Methods Immunophenotyping was performed in 108 adult and 53 childhood B-ALL by flow cyto metry and a panel of monoclonal antibodies. Results The incidence of myeloid-associated antigen (CD13,CD33) expression was higher in CD34 positive cases than in CD34 negative B-ALL. There was no difference in the expression of CD34,myeloid or T lymphoid antigen between adult and childhood cases. Conclusion Myeloid positive B-ALL might originate from the malignant transformation of early hemotopoietic stem cells.The immunophenotypic features were similar between previously untreated adult and childhood B-ALL.更多还原