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惊厥性与非惊厥性癫痫持续状态的临床研究

Clinical study on convulsive and nonconvulsive status epilepticus in children

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【作者】 王艺张瑾孙道开

【Author】 WANG Yi, ZHANG Jin, SUN Daokai Children’s Hospital of Shanghai Medical University, Shanghai 200032,China

【机构】 上海医科大学儿科医院

【摘要】 目的 比较惊厥性癫痫持续状态 (CSE)和非惊厥性癫痫持续状态 (NCSE)的临床诊断和治疗 ,以提高对NCSE的临床诊疗水平。方法 对 71例临床发作和脑电图检查符合癫痫持续状态的病例进行分析。结果  5 1例CSE和 2 0例NCSE比较 :1.NCSE组临床表现多样。 2 .发作平均持续时间不同 ,CSE 3.5± 2 .9h ,NCSE6 .1± 4.9d。 3.CSE与NCSE脑电图表现不同。 4.2 4h内明确诊断者CSE和NCSE分别为 10 0 %和 2 5 %。 5 .开始治疗至临床发作控制的时间CSE 1.1± 0 .9d ,NCSE 5 .3± 4.1d(P <0 .0 1)。结论 NCSE为癫痫持续状态的常见类型 ,与CSE相比具有更为复杂的临床和脑电图表现以及治疗时间长等特点。

【Abstract】 Objective To compare the clinical diagnosis and treatment of convulsive status epilepticus(CSE) with those of nonconvulsive status epilepticus(NCSE) and to improve the treatmnet and diagnosis of NCSE. Methods 71 cases were analyszed, whose clinical seizure episodes and electroencephalograph were coincident with status epilepticus. Result The clinical manifestations and EEG in NCSE patients were various. The average duration of seizures in CSE and NCSE were 3.5±2.9 hours and 6.1±4.9 days respectively with significant difference. The percentage of definite diagnosis within 24 hours in CSE was 100%, but only 25% in NCSE. The time from beginning of therapy to clinical control of seizure in CSE and NCSE were 1.1± 0.9 days and 5.3±4. 1 days (P<0.01). Conclusions NCSE is a common type in SE in children. Patients with NCSE have more diverse clinical features and need longer course of treatment compared with those of CSE.

  • 【文献出处】 实用儿科临床杂志 ,JOURNAL OF APPLIED CLINICAL PEDIATRICS , 编辑部邮箱 ,2000年02期
  • 【分类号】R742.1
  • 【被引频次】13
  • 【下载频次】307
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