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消化道恶性肿瘤患者血清可溶性肿瘤坏死因子受体-Ⅰ的检测及其临床评价

Detection and its clinical significance of serum soluble tumor necrosis factor receptor-Ⅰ in patients with malignant carcinoma of digestive system

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【作者】 王瑞华； 许培仁； 陈树恩； 赵冬梅；

【Author】 Wang Ruihua,Xu Peiren,Chen Shuen,et al. Department of Digestive Medicine,The Affiliated Hospital of Kaifeng Medical College,Kaifeng 475000

【机构】 开封医学高等专科学校附属淮河医院消化内科!475000；

【摘要】 目的　了解可溶性肿瘤坏死因子受体 -Ⅰ (sTNFR -Ⅰ )在消化道恶性肿瘤患者中的临床意义。方法　应用双抗体夹心ELISA法 ,对 37例食管癌、41例胃癌、30例大肠癌患者血清sTNFR -Ⅰ水平进行了检测。结果　三组肿瘤患者血清sTNFR -Ⅰ水平显著高于对照组 ,且随肿瘤临床病理分期增加而增高 ,有转移者显著高于无转移者。手术切除肿瘤后sTNFR -Ⅰ水平下降 ,肿瘤复发时sTNFR -Ⅰ水平上升。结论　检测血清sTNFR -Ⅰ水平有助于消化道恶性肿瘤患者的诊断及预后判断

【Abstract】 Objective To define the clinical significance of serum soluble tumor necrosis factor receptor-Ⅰ(sTNFR-Ⅰ) in patients with malignant carcinoma of digestive system.Methods Measure serum levels of sTNFR-Ⅰusing ELISA technique in 37 patients with esophaged carcinoma(EC),41 patients with gastric carcinoma(GC),30 patients with colorectal carcinoma(CC).Results The levels of sTNFR-Ⅰwere significantly higher in patients with EC,GC and CC than in controls .The more advanced the clinicopathologic stage of malignant tumor,the hig