【摘要】 目的　研究粘着斑激酶 (FAK )在胃癌及癌旁组织中的表达及其与肿瘤细胞分化、浸润、转移等生物学行为的关系。方法　应用免疫组织化学ABC法检测 75例胃癌及癌旁组织石蜡标本中FAK蛋白的表达水平。结果　FAK在癌组织中的表达明显高于癌旁组织 ,低分化癌组织较高分化、中分化组织中FAK的表达高 ,有淋巴结转移的组织较无转移的表达高 ,浸润程度越深表达越高。结论　FAK可能既是 1种转化相关酶又是 1种演变相关酶。FAK的表达量可作为肿瘤发生、发展过程中 1种较有价值的病理指标。更多还原

【Abstract】 Objective To obtain the pattern of the FAK expression in gastric carcinoma and noncancerous tissue.Further,to get the correlation between expression of FAK and clinicopathalogical data including tumor differentiation,infiltrating and lymph node metastasis.Methods Expression of FAK was examined in 75 gastric carcinomas by immunohistochemical technique.Results The staining of FAK was stronger in gastric carcinomas than in the epithelia cell of noncancerous areas and was higher in low differentiation cancer cell than in well differentiationenes.The cancers with lymph node metastasis had more FAK protein than the cancers without lymph node metastasis and the deeper extent of infiltrating,the higher FAK expression was.Conclusion The FAK might be not only a transformation linked enzyme but also a progression linked enzyme.The level of FAK expression might be a valuable marker for the carcinogenesis and the progression of the carcinoma.更多还原