【摘要】 目的　探讨血清新喋呤水平与肺癌的关系及其临床意义。方法　采用酶联免疫吸附竞争抑制法检测了 3 2例健康献血员、43例肺癌患者的血清新喋呤水平。结果　初诊肺癌患者血清新喋呤水平为 ( 5 .7± 3 .4) μg/L ,显著高于正常对照组的 ( 1.5±0 .7) μg/L(P <0 .0 1)。除N2 期患者血清新喋呤水平较高以外 ,不同病期、不同病理类型的肺癌患者血清新喋呤水平无显著性差异。结论　肺癌患者存在异常的细胞免疫应答 ,检测血清新喋呤水平可作为判断肺癌患者细胞免疫功能的 1个客观指标。更多还原

【Abstract】 Objective To evaluate the changes of serum neopterin in patients with lung cancer.Methods The serum levels of neopterin were determined in 32 healthy adults and 43 lung cancer patients by competitive enzyme immunoassay.Results The serum neopterin concentration of patients before anti tumor therapy was significantly higher than that of the healthy adults(5.7± 3.4 ) μg/L vs (1.5±0.7) μg/L, P <0.01.Neither the disease stage nor the pathologic classification had any correlation with serum neopterin values.Conclusion Cellular immunity might be involved in the pathogenesis of lung cancer,the measurement of the serum neopterin level may be used as an objective index in the evaluation of the cellular immunological function in patients with lung cancer.更多还原