【摘要】 目的　观察立体定向放射治疗 (SRT )应用于脑胶质瘤患者治疗的疗效。方法　采用SRT治疗 41例脑胶质瘤患者 ,其中初治患者 3 0例 ,复发者 11例。单次治疗 (SRS) 3 2例 ,分次治疗 (FSRS) 9例。SRS和FSRS的中位靶区周边剂量分别为 2 0Gy和 3 6Gy。 2 6例SRS和 8例FSRS患者分别接受中位剂量为 40Gy和 3 0Gy的外照射。中位随访期为 2 2个月 ( 9～ 3 4个月 )。结果　全组局部病灶控制率为 63 .4%,中位生存期 (MST )为 11.5个月 ,其中SRS和FSRS组MST分别为 11和 16.5个月 ;初治和复发者MST分别为 17和 8.5个月。全组 1年和 2年生存率分别为 5 4%和 3 4 %。结论　SRT可加强局部病灶控制 ,对瘤体较小、边界清晰的胶质瘤可作为 1种安全有效的辅助治疗手段。更多还原

【Abstract】 Objective To evaluate the efficacy of stereotactic radiotherapy(SRT) in patients with glioms.Methods 41 patients with gliomas were treated with SRT.There were 30 newly diagnosed patients and 11 recurrent patients.32 patients were treated with stereotactic radiosurgery(SRS),and 9 received treatment with fractionated stereotactic radiosurgery(FSRS).Median dose to the periphery of tumor volume were 20 Gy for patients in SRS group and 36 Gy in FSRS group.26 patients in SRS group and 8 in FSRS group received external beam radiotherapy,and the median dose was 40 Gy and 30 Gy,respectively.Median follow up period was 22 months(range,9～34 months).Results The local control rate was 63.4% and median survival time(MST) was 11.5 months for all patients,11 months for SRS group,16.5 months for FSRS group,17 months for newly diagnosed patients and 8.5 months for recurrent patients.The one year and 2 year overall survival rates were 54% and 34%,respectively.Conclusion SRT can improve the local control,and may privide a safe and effective adjunct to other modalities for patients with small,radiographically well defined gliomas.更多还原