【摘要】 目的　对 30例散发性肾母细胞瘤WT1基因缺失进行检测 ,并分析其与组织类型的关系。方法　采用Southern印迹分子杂交技术。结果　 2例WT1基因内缺失为间质优势型肾母细胞瘤。结论　肾母细胞瘤的病因学十分复杂 ,WT1基因缺失可能与间质优势型肾母细胞瘤的发生有关。更多还原

【Abstract】 Objective To study WT 1 gene from 30 cases of sporadic wilms tumor.Methods WT 1 gene was studied by Southern bolt hybridization with WT 1 cDNA probe.Results Two cases with intragenic deletions of WT 1 gene were histologically classified as stroma predominated wilms’ tumor. Conclusion The etiology of wilms’ tumor is complex, the deletion of WT 1 gene may be correlated with stroma predominated wilms tumor.更多还原