【摘要】 目的　探讨尿激酶(UK)和前列腺素(PGE1)联合给药对急性心肌梗死(AMI)6h内入院患者进行静脉溶栓的疗效观察。方法　分为UK+PGE1组(32例)及UK组(49例);UK用量为2万U/kg,PGE1用量为300～400μg/次。两组年龄、性别、发病至用药时间均无差异。结果　联用组再通23例,再通率71.9%;再阻塞2例,再阻塞率8.7%;住院死亡2例,病死率6.2%。单用UK组上述分别为28例(57.1%);6例(21.4%);5例(10.2%)。结论　联用组比单用组再通率高,而再阻塞率及住院病死率明显降低。并且PGE1未增加UK出血之发生,且PGE1副作用小,为安全、有效药物。更多还原

【Abstract】 Objective To observe the thrombolytic effect of intravenous urokinase (UK) plus prostaglandin E 1(PGE 1) on acute myocardial infarction (AMI) within six hours.Methods All cases were divided into UK plus PGE 1 group (n=32) and UK alone group (n=49).The dose of UK and PGE 1 was 2×10 4 IU/kg and 300～400 μg respectively.Between the two groups there was no differences in age,sex and the time of onset to thrombolysis.Results In UK plus PGE 1 group,the rates of recanalization,reocclusion and mortality were 71.9% (23 cases),8.7% (2 cases) and 6.2% (2 cases) respectively.In UK alone group,its were 57.1% (28 cases),21.4% (6 cases) and 10.2% (5 cases) respectively.Conclusion The recanalization rate of UK plus PGE 1 was higher than that of UK alone,the rates of reocclusion and mortality in the former were lower than those in the latter.Intravenous UK plus PGE 1 is an effective and safe thrombolytic method for AMI.更多还原