【摘要】 目的　观察迟发性佝偻病并发哮喘的治疗反应 ,探讨维生素D(VD)缺乏在哮喘发病中的作用。方法　 31例迟发性佝偻病并发哮喘患儿随机分成A、B两组 ,15例单纯哮喘患儿为C组。 3组均吸入二丙酸倍氯米松气雾剂 (becotideinhaler) 1年 ,A组另加VD3 治疗。于治疗前后分别测定肺功能等。结果　治疗前 3组用力呼气一秒量 (FEV1 0 )及用力呼气峰流速(PEF)均减低 ,但组间无差别 ;A、B两组骨钙素和反映气道敏感性的Dmin值较C组低 ,且A、B两组骨钙素与Dmin值呈正相关。治疗后 3组FEV1 0 和PEF比治疗前均有提高 ,A组提高最明显 ;气道敏感性较治疗前降低 ,其中A组最显著。B组骨钙素明显下降。结论　VD缺乏易致佝偻病患儿气道敏感性增加 ,骨钙素水平降低。对迟发性佝偻病并发哮喘在吸入皮质激素的同时加适量VD治疗可提高疗效 ,减少副作用。更多还原

【Abstract】 Objective To observe the response to treatment in asthmatic children with late richets, and study the role of vitamin D(VD) deficiency in asthma. Methods Thirty-one asthmatics with richets were divided into group A and B at random, and other 15 asthmatics without richets regarded as group C.All inhaled beclomethasone dipropionate and group A got an injection for VD 3. At pre-and post-treatments, lung function were determined. Results Before treatment,the subjects showed an average fall in FEV 1 0 and peak expiratory flow (PEF).But no difference was found among the 3 groups. Compared with group C,groups A and B showed decrease in plasma OC level and D min , and OC level was correlated with D min ( r=0 678,P<0 05 ).One year treatment resulted in an improvement of lung function (FEV 1 0 and PEF) and decrease of airway sensitivity among the 3 groups, especially group A. Contrast with group A, groups B and C showed decrease in plasma OC. The decrease of group B showed significent difference with pre-treatment ( P<0 01).Conclusion Late richets is subjected to airway hypersensitivity and low OC level by VD deficiency. The treatment with inhaled corticosteroids and VD can reduce asthma attack episodes and side effects. [WT5”HZ]更多还原