【摘要】 在哺乳动物细胞中 ,程序性细胞死亡 (PCD)的功能元件包括死亡受体、适配体蛋白、效应元件及调节元件。凋亡信号由适配体蛋白传导至效应元件———Asp特异性半胱氨酸蛋白酶 (Caspase) ,活化的Caspase水解一系列关键底物 ,最终导致细胞解体。Bc1 -2家族、IAPs家族、ARC和FLIPs等蛋白因子通过与适配体蛋白及Caspase的相互作用来调控PCD进程。更多还原

【Abstract】 In mammalian cells,functional elements of progrmmed cell death(PCD)or apoptosis include death receptors,adaptor proteins,effectors and regulators.apoptotic signal is conducted to effective elements which is Asp-specific cysteine protease(Caspase).Activated Caspases cleave a set of key substrates,leading to cell disassembly ultimately.Proteins,including Bcl-2 family,IAPs family,ARC and FLIPs,can regulate the process of PCD by interacting with adaptors and Caspases.更多还原