【摘要】 目的　评价泡利芬的抗脂质过氧化作用。方法　将 5 3 5例尘肺病人分为矽肺宁、高剂量茶多酚、VitC和低剂量茶多酚 4组。前后两组分别服药 3个月和 6个月。测定服药前、服药第 3和 6个月时的血清超氧化物歧化酶(SOD)、铜蓝蛋白 (CP)和过氧化脂质 (LPO)水平。结果　服药 3个月时 ,除矽肺宁组外 ,其余 3组SOD活性均下降 ;低剂量茶多酚组和VitC组LPO水平降低 ;各组CP均较服药前为低。第 6个月时 ,低剂量茶多酚组SOD和CP低于服药前 ;LPO与服药前无差异 ;VitC组只有CP低于服药前。结论　泡利芬具有抗脂质过氧化作用更多还原

【Abstract】 Objective To evaluate the possible anti oxidation effect of Polifen,a tea polyphenols(TP)preparation.Method 535 patients with coal workers pneumoconiosis(CWP)were randomly divided into four groups,respectively took Xifeining(for three months),high concentration Polifen(for three months),Vitamin C,(for six months),and low concentration of Polifen(for six months).Then,serum superoxide dismutase(SOD),lipid peroxide(LP)and ceruloplasmin(CP)activities were determined before and at the end of administration.Results At the end of three month administration,SOD activities in all groups were significantly decreased except the group treated with Xifeining;significant decreases in LPO levels were observed in low concentration Polifen group and vitamin C group;all the four groups showed significant decreases in CP activities.After six month administration,all three indices remained lower than those before administration in the groups treated with low concentration Polifen,although the differences in LPO was statistically insignificant;only CP activities were significantly decreased three month of administration in vitamin C group.Conclusion The Polilen preparation has the effect in anti lipid peroxidation.更多还原