【摘要】 用核团或侧脑室微量注射、微电极细胞外单位放电记录及清醒动物胃运动记录等方法 ,观察了大鼠下丘脑腹内侧区 (ventralmedialhypothalamus,VMH)或侧脑室内 (icv)微量注入胃动素 (motilin)对延髓迷走复合体 (dorsalvagalcomplex ,DVC)神经元电活动和胃运动的影响。结果表明 :(1)VMH注入胃动素会改变DVC胃相关神经元的电活动 ;(2 )VMH及侧脑室内注入胃动素可使清醒大鼠胃运动增强 ;(3)膈下迷走神经切断会取消VMH增强胃运动的作用。上述结果提示 ,中枢注入的胃动素可能作为促进胃运动的调节因子参与中枢增强胃肠的调控 ,下丘脑 延髓 迷走神经可能是实现其作用的通路更多还原

【Abstract】 To investigate the effect of microinjection of motilin into ventral medail hypothalamus (VMH) or intracerebroventricle (icv) on gastric motility, extracellular unit responses of dorsal vagal complex (DVC) in anesthetized rats and gastric motility of conscious rats were recorded. The results are as follows. (1) The firing rate of gastric distention related neurons in DVC was modified. (2) VMH and icv administration of motilin induced obvious enhancement in gastric motility. (3) The effect of motilin on gastric motility was abolished by vagotomy. These results imply that central motilin appears to work as an excitatory neuromodulator in the regulation of gastric motility through VMH DVC vagal nerve axis.[WT5HZ]更多还原