【摘要】 目的　评估中药复方“更年春”治疗原发性骨质疏松（ＰＯＰ）的疗效，并探讨其机制。方法　将１０～１２月龄ＳＤ雌性大鼠５０只随机分成５组：假手术组、模型组、中药高剂量组、中药低剂量组、尼尔雌醇组，除假手术组做假性手术外，其余各组均行双侧卵巢切除术，术后３个月起灌药，３个月后取大鼠椎骨、胫骨作组织切片观察，并作形态计量分析。结果　组织切片观察显示，中药及尼尔雌醇组骨小梁比模型组粗壮饱满，结构完整。形态计量分析显示，中药及尼尔雌醇组骨小梁面积均数明显高于模型组（Ｐ＜０．０１）。结论　中药更年春可用于治疗绝经后骨质疏松。更多还原

【Abstract】 Purpose To evaluate the effect of Chinese herbal formula gengnianchun (GNC) on primary osteoporosis. Methods Fifty female SD rats of 10-12 months old were randomly divided into five groups.In every group rats were ovariectomized bilaterally,except in one group with sham operation,one group treated with nilestriol,two groups fed respectivly with high and low dosage of GNC,two groups fed with water.Three months later after operation,all rats were fed daily with medicine for three months.Then pathomorphology and histomorphometry of the tibia and vertebra of rats in five groups were observed. Results The trabecular bone were more widened and less broken in rats of groups treated with GNC and nilestriol than that in rats of model group.Histomorphometry analysis revealed that GNC and nilestriol can increase significantly the mean trabecula area of vertebra and tibia in comparison with model group ( P < 0.01 ). Results The trabecular bone were more widened and less broken in rats of groups treated with GNC and nilestriol than that in rats of model group.Histomorphometry analysis revealed that GNC and nilestriol can increase significantly the mean trabecula area of vertebra and tibia in comparison with model group ( P < 0.01 ). Conclusions These data indicated that GNC may treat osteoporosis in postmenopausal patients.更多还原