【摘要】 目的　研究顺铂双路化疗在晚期口腔鳞癌治疗中的作用。方法　采用颈外动脉插管灌注顺铂、平阳霉素及 5 -氟脲嘧啶 ,同时静脉滴注硫代硫酸钠解毒的方法治疗晚期口腔鳞癌 2 3例 ,连续使用 5 7d为一疗程。顺铂的总剂量达 15 0mg以上时进行疗效判断。结果　除 1例因插管后出现暂时性肢瘫拒绝化疗 ,1例顺铂剂量不足15 0mg外 ,特效 7例、显效 11例、无效 3例 (肿瘤缩小不足 5 0 % ) ,总有效率 85 7%。除Ⅰ Ⅱ级的胃肠道反应、发热、局部水肿、脱发外 ,未发现明显肝、肾、肺、造血系统的功能损害。结论　顺铂双路疗法是晚期口腔鳞癌的一种安全、有效的治疗手段更多还原

【Abstract】 Objective To study the feasibility and efficacy of two-route cisplatin chemotherapy for locally advanced squamous cell carcinoma of oral cavity.Methods 23 cases with clinical advanced biopsy-proven oral squmous cell carcinoma received intraarterial chemotherapy with cisplatin (DDP),Pingyangmycin (PYM) and 5-fluorouracilum(5-Fu),at the same time intravenous infusion with natrii thiosulfas (STS) for rescue. DDP at 40-60mg/d,PYM at 16mg/d and 5-Fu at 500mg/d were applied for 5-7 consecutive days.Results 7 cases (33.3%) obtained a complete response (CR),11(52.4%) had partial response (PR) with an objective response rate (RR) of 85.7%. No severe toxicity was observed,whereas the most frequent grade Ⅰ and Ⅱ drug-related toxicities were nausea and vomiting. No nephrotoxicity,hepatotoxicity and severe bone marrow suppression were noted. Conclusion Two-route cisplatin chemotherapy is,in our experience,a new,effective and safe therapeutic method for oral squamous cell carcinoma. [更多还原