【摘要】 血管内皮层具有重要的生理功能。血流剪应力作用影响内皮细胞的形态结构。功能、增殖和迁移过程，其作用是通过应力转导途径实现的。对应力转导的深入研究，不仅揭示了人体血管内的许多生理过程，解释动脉粥样硬化等心血管疾病的病理机理，而且可将其机理应用于改进临床治疗手段。更多还原

【Abstract】 Vascular endothelium plays an important role in maintaining vascular morphology and biologic functions. Fluid shear stress influences the morphology, function, proliferation and migration of endothelial cells via mechanotransduction pathway. Knowledge on mechanism of mechanotransduction not only allows defining the physiological and pathological process in vascular system, but also has clinical applications for the development of new and effective treatments.更多还原