【摘要】 目的 :测定子宫内膜癌及卵巢癌患者血清层粘蛋白 (laminin,L N)含量及切除肿瘤对其影响。方法 :用放射免疫法测定 14例子宫内膜癌 ,2例子宫内膜增殖症 ,8例卵巢癌 ,76例妇科良性疾病患者术前及部分内膜癌和卵巢癌术后血清 L N含量 ,还测定了 4例卵巢癌腹水中的含量。结果 :子宫内膜癌患者血清 L N明显高于子宫内膜增殖症及其他各良性疾病组 (P<0 .0 5 )且与肌层浸润程度有关 ,卵巢癌血清 L N也明显高于各良性疾病组但统计学分析无差异 ,其腹水 L N明显高于血清 (P<0 .0 5 ) ;手术切除肿瘤后 ,两种恶性肿瘤血清 L N水平均显著下降 (P<0 .0 5 )。结论 :血清及腹水 L N水平与肿瘤的浸润过程密切相关 ;观察其变化对子宫内膜癌及卵巢癌的诊断、病情判断及监测可能有一定参考价值更多还原

【Abstract】 Objective:To determine the contents of laminin(LN)in serum and ascites in patients witn endometrial adenocarcinoma and ovarian cancer before and after resection of the tumor.Methods:Radionimmunoassay(RIA)method was used to measure LN′s contents in serum and ascites.Serum were obtained from 14 endometrial adenocacinoma patients and 8 ovarian cancer patients before operation,12 and 5 cases after operation respectively;2 hyperplastic endometrium patients and 76 benign gynecologcal disease patients.Ascites were collected from 4 cases of ovarian cancer.Results:The contents of LN in serum in cancer group is significently higher than in non-serum cancer group( P <0.05),The level of LN in serum become high with depth of myometrial invasion in endomtrial adenocarcinoma;After recection of the tumor the level of Laminin in serum from those two cancers was decreased rapidly( P <0.05);The level of LN in ascites is obviously higher than in serum( P <0.05).Conclusion:Changes of the contents of LN in serum and ascites are closely related to the tumor invasion and metastases;The assay of LN in serum and in ascites might be useful to the diagnosis and supervision of endomtrial adenocarcinoma and ovarian cancer.更多还原