【摘要】 目的 :研究引起外阴阴道念珠菌病 (vulvovaginal cnadidiasis,VVC)的真菌种类的变迁 ,评价口服伊曲康唑及阴道应用硝酸咪康唑治疗 VVC的疗效。方法 :对 1998年 3月至 1999年 8月在我院门诊就诊的 12 3例 VVC患者阴道分泌物进行真菌培养并将其随意分为口服伊曲康唑组 (5 0例 )和阴道应用硝酸咪康唑组 (73例 )。用药后 1周和 4周进行随诊。结果 :1白色念珠菌为引起 VVC的主要病原 ,占 82 .1%(10 1/ 12 3例 ) ,其次为近平滑念珠菌 (4.88%)及热带念珠菌(4.88%)。2口服伊曲康唑组和阴道应用硝酸咪康唑组用药后 1周的治愈率分别为 88.0 %和 82 .2 %(P>0 .0 5 ) ,用药后4周的治愈率分别为 86 .7%和 89.6 %(P>0 .0 5 )。 3白色念珠菌所致 VVC的治愈率明显高于非白色念珠菌所致 VVC的治愈率 ,分别为 88.1%和 6 8.2 %,P<0 .0 5。结论 :白色念珠菌仍为 VVC的主要病原 ,口服伊曲康唑和阴道应用硝酸咪康唑治疗 VVC均有较好疗效 ,对白色念珠菌所致 VVC的治疗效果好于治疗非白色念珠菌所致 VVC。更多还原

【Abstract】 Object:To study the fungal population of vulvovaginal candidiasis (VVC) and to evaluate the curative effects of oral itraconazole and topical miconazole for VVC.Methods:One hundred and twenty two outpatients with VVC(1998.3～1999.8)were devided randomly into oral group and topical group,and vaginal samples were cultured by mycology.Results:①Candida albicans,was the predominant yeast isolate for VVC(82.1%),Candida parpsilosis,Candida tropicalis and other candida species made up the remainder.②The cure rates of oral group and topical group were 88.0% and 82.2%( P >0.05)in the first week follow up and 86.7%and 89.6%( P >0.05)in the forth week follow up.③The cure rate of VVC caused by Candida albicans(88.1%)was higher than those caused by non Candida albicans( 68.2% ), P <0.05.Conclutions:Oral itraconazole and topical miconazole have the same curative effects of VVC.The VVC due to Candida albicans is still the predominant yeast isolate of VVC,The VVC due to Candida albicans is higer than those caused by non Candida albicnas.更多还原