【摘要】 对 6 5例胃、十二指肠疾病患者和 36例健康人行 1 3 C-尿素呼气试验 (C- UBT)、病理组织学和快速尿素酶(RUT)三种方法检测幽门螺杆菌 (HP) ,其中任两项阳性者认为有 HP感染。结果显示 ,C- U BT、病理组织学和 RUT检测的阳性率分别为 81.5 4%、83.1%、84.6 2 % ;敏感性分别为 96 .2 3%、86 .8%、84.91% ;特异性分别为 10 0 %、91.6 7%、83.33%。认为 C- UBT和病理组织学是检测 HP感染较准确的方法 ,RU T的敏感性与特异性较前两种方法低 ,其操作方便 ,费用低 ,仍是临床常用的检测手段 ,但不能单独作为诊断 HP感染指标。病理组织学和 RU T均为侵入性检查 ,取材也受“灶性”分布的影响 ,而 C- UBT是非侵入性操作 ,更能反映“全胃”HP感染状况 ,临床应用时无任何禁忌和限制 ,如果仅为了检测 HP状态或抗 HP药物疗效监测 ,C- UBT可替代病理组织学及 RUT检查。更多还原

【Abstract】 C urea breath test([KG3/5] 13 C UBT),histology and rapid urase test(RUT) were used in diagnosing helicobacter pylori(HP) infection in 65 patients with gastric and duodenal ulcer,and 36 nomal persons.Any two tests of the above three were positive,the HP fection was confirmed.Results showed that the positive rate of [KG3/5] 13 C UBT,histology and RUT were 81 54%,83 1%,84 62%and 96 23%,86 8%,84 91%,and 100%,91 67%,83 33% specificity.This suggest the [KG3/5] 13 C UBT and histology are sensitivity and specificity in diagnosing HP infection.Though the sensitivity and specificity of RUT are lower,it is clinicaly accepted for its convenience and low cost,but it should not be employed alone in diagnosing HP infection.Histology and RUTare invasive, easily biased by the loci of biopsy,while [KG3/5] 13 C UBT is non-invasive,no contraind cations and restrictions,and it can reflect the whole stomach.So the [KG3/5] 13 C UBT can replace the other two methods in the diagnosis of HP infection or the surveillace of anti-HP drug therapy.更多还原