【摘要】 检测 41例不同级别脑胶质瘤标本和 7例正常脑组织 P1 6 蛋白表达情况和 PCNA指数。结果 :实验组P1 6蛋白表达缺失 2 7例 ,占 6 5 .85 %。P1 6蛋白表达缺失率和 PCNA指数随脑胶质瘤恶性程度级别增高呈上升趋势(P<0 .0 5 )。 PCNA指数与 P1 6 蛋白表达具有明显相关性 (P<0 .0 1)。表明 P1 6 蛋白是脑胶质瘤细胞周期和肿瘤细胞增殖活性的重要调控因子更多还原

【Abstract】 To study the relationship between P 16 protein expression and the malignant grades of brain glioma and the proliferation activity of tumor cells,the P 16 and PCNA protein expression were detected in 41 brain glioma specimen with different grades and 7 normal brain tissue specimen The results showed in the experimental group,the deletion of P 16 protein expression were found in 65 9%(27/41)cases The deletion of P 16 protein ex[KG(-30]pression and increase of PCNA index were related to the increase of malignant grade of brain glioma significantly(P<0 05) Also the P 16 protein expression was related to the change of PCNA index dominantly(P<0 01) We conclude the abnormity of cell cycle modulation and increase of cellular proliferation activity are caused by deletion and mutation of P 16 gene is an important factor to influence the biological characteristics of brain glioma更多还原