【摘要】 对２４例慢性乙型肝炎（下称慢乙肝）患者于肝穿同日留取血清，分别进行肝组织ＨＢＶ－ＤＮＡ、血清ＨＢＶ－ＤＮＡ定量检测及血清ＨＢｅＡｇ量的测定，　并比较肝组织与血清ＨＢＶ－ＤＮＡ定量的差异，分析肝组织ＨＢＶ－ＤＮＡ定量与血清ＨＢＶ－ＤＮＡ定量、ＨＢｅＡｇ量及肝功能指标之间的相关性，比较各型慢乙肝肝组织ＨＢＶ－ＤＮＡ定量的差异。结果显示，肝组织ＨＢＶ－ＤＮＡ定量明显高于血清ＨＢＶ－ＤＮＡ定量，二者的对数值呈显著相关；肝组织ＨＢＶ－ＤＮＡ定量与ＨＢｅＡｇ量呈中度相关，与血清谷丙转氨酶（ＡＬＴ）、总胆红素（ＴＢＩＬ）、白蛋白与球蛋白之比（Ａ／Ｇ）无关，各型慢乙肝肝组织ＨＢＶ－ＤＮＡ定量无统计学差异。提示肝组织ＨＢＶ－ＤＮＡ定量较血清ＨＢＶ－ＤＮＡ定量、ＨＢｅＡｇ量更能反映肝内ＨＢＶ复制水平，具有重要的临床意义。更多还原

【Abstract】 The HBV-DNA in liver and serum specimens from 24 patients with c hronic hepatitis B(CHB)were detected by PCR quantitatively,and the serum HBeAg w as semi quantified by ELISA The HBV-DNA quantity in Liver tissue and HBV-DNA qua ntity in serum were compared,the relationships among liver HBV-DNA quantity,serum HBV-DNA quantity and serum HBeAg level were analysised The results showed that the Liver HBV-DNA quantity was much hig her than serum HBV-DNA quantity and ther e was statistical difference between them (P<0.05) It was notable that liver HBV -DNA quantity was as high as 700～5000fg/ml in three patients whose serum HBV-DNA quantity was<0 5fg/ml Liver HBV-DNA qua ntity had close、positive correlation wit h serum HBV-DNA,medium postive correlati on with serum HBeAg level,no correlation with serum ALT,TBIL and A/G There was n o difference among liver HBV-DNA quantit y in every type of CHB and cirrhosis The results indicates that liver HBV-DNA qu antity is amore accurate assessment of H BV replication than serum HBV-DNA quanti ty and HBeAg level,it showld become an i mportant part of pretreatment evaluation and assessment of treatment efficacy更多还原