【摘要】 采用免疫组织化学方法检测 85例食管鳞癌 nm2 3蛋白表达。结果 34例 (4 0 % )呈 nm2 3阴性表达。nm2 3阴性表达与肿瘤的浸润深度、淋巴结转移和 TNM分期有关 (P=0 .0 1、P=0 .0 0 1和 P=0 .0 0 1)。nm2 3低表达的肿瘤患者与正常表达者相比 ,淋巴结转移的风险比例 (OR值 )为 72 .187。因此认为 ,对原发瘤或活检组织 nm2 3的免疫组化检测有可能成为评价食管鳞癌肿瘤分期及淋巴结转移的一个有价值的预测指标。更多还原

【Abstract】 WT5BZ]The expression of nm23 protein was examined by immunohistochemical methods in resected esophageal squamous cell carcinoma(ESCC)specimens from 85 cases Results showed that 34 cases (40%)were nm23 negative expression The rate of nm23 negative expression increased with serosal invasive,lymph node metastasis and tumor staging(P<0 05,P<0 01 and P<0 01,respectively) The risk of nodal metastasis was higher in the patients with negative expression of nm23 than those positive,the odds ratio was 72 187(95%CI,9 06,575 22) The results suggested that immunohistochemical evaluation of nm23 in the primary tumor or in a biopsy may be a useful forecasted predictor for the stage of disease and presence of lymph node metastasis in ESCC [WT5HZ]更多还原