【摘要】 目的 :验证损伤和感染引发上皮破裂、启动息肉的形成机制 ,探索其临床意义。方法 :2 7只新西兰白兔 ,局部麻醉后在直径 2 .7mm内窥镜下切除一侧部分鼻甲 ,并按不同的填塞方法分成 4组 :( 1 )地塞米松加卡那霉素液加明胶海绵 (地卡组 ) ,( 2 )生理盐水组 ,( 3)金黄色葡萄球菌液加明胶海绵 (金葡菌组 ) ,( 4 )不填塞组。另一侧作对照 ,分别在 7,1 4,2 1 ,2 8,35d后处死动物 ,光镜观察。结果 :2只动物在手术中死亡。 2 5只动物 ( 50侧 )中息肉形成 7侧 ( 1 4% ) ,金葡菌组有 3侧 ,对照侧有 2侧 ,不填塞组有 2侧。金葡菌组息肉发生率与对照侧差异无显著性 ( P>0 .0 5) ,不填塞组与对照侧差异有高度显著性 ( P<0 .0 1 )。囊泡和肉芽等息肉前期改变 2 4侧 ( 4 8% )。地卡组 5侧 ( 2 5% ) ,随时间延长发生率逐渐下降 ;生理盐水组囊泡和肉芽各 1侧( 2 5% ) ;不填塞组 8侧 ( 80 % ) ,随时间延长数量逐渐增多。金葡菌组 9侧 ( 75% ) ,其发生率不随时间延长而改变 ,但其对照侧的囊泡随时间延长而减少。地卡组、NS与金葡菌与不填塞 4组比较 ,息肉、囊泡、肉芽发生率差异有显著性 ( P<0 .0 5)。地卡组与 NS组 ,金葡菌组与不填塞组两两比较差异无显著性。结论 :粘膜上皮损伤是引发息肉的原因之一 ,如伴感染、炎症可增?更多还原

【Abstract】 Objective: To investigate the mechanism of rupture of epithelial cells and formation of nasal polyps caused by injury and infection.Methods: Twenty seven New Zealand white rabbits were locally anestheted,and the unilateral nasal turbinate were resected under endoscope of 2.7 mm in diameter.According to the methods of filling,the animals were divided into four groups,(1)its nasal cavity were blocked with gelfoam with dexamethason and kanamycin (DK),(2) blocked with normal saline (NS),(3) blocked with gelfoam with gold staphylococcus(GS),(4)no blocked(NO).Other laterals were as control.The animals were killed after 7,14,21,28,35 days respectively.Specimen were observed by light microscope.Results:Two died in operation,the other 25(50 laterals) were studied.Seven (14%) laterals had polyps,of them,3 were in GS,2 in control group,2 in NO group.Twenty four (48%) laterals had granulation and cyst,of them,5 laterals were in DK, 2 in NS,8 in NO and 9 in GS.Conclusions: Rupture of the epithelium could be one of the pathogenesis of nasal polyps.With infection and inflammation,the number of the polyps would increase.The cyst and granulation could be diverted by topical applying hormone or blocking a suitable material such as gelatin.The polyps recurrence could be avoided if mucous injury were avoided in operation and inflammation were controlled.更多还原