【摘要】 目的 :了解脂蛋白 (a)〔Lp(a)〕单独或与其他血脂试验串联用于诊断冠心病的真实性。 方法 :以 1∶1配比方法收集 87对病例及对照 ,采用盲法检测其血清Lp(a)、总胆固醇 (TC)、高密度脂蛋白胆固醇(HDL C)、低密度脂蛋白胆固醇 (LDL C)等指标 ,并以灵敏度、特异度、假阳性率、假阴性率和粗一致性 5个指标评价诊断试验的真实性。结果 :①Lp(a)单独用于冠心病诊断时 ,最优截断值为≥ 0 .2 5g/L ,此时 ,粗一致性为 62 0 7%、灵敏度为 60 92 %、特异度为 63 2 2 % ;②该试验诊断冠心病的真实性仅优于HDL C ;③Lp(a)分别与TC、HDL C、LDL C、LDL C/HDL C串联用于冠心病诊断 ,粗一致性为 62 97%～ 67.2 4 %。结论 :Lp(a)作为冠心病诊断试验 ,真实性不够理想更多还原

【Abstract】 Objective:To evaluate the validity of lipoprotien(a)[Lp(a)] concentration as diagnostic test for Coronary Heart Disease (CHD)by itself or serialized with other blood lipids.Method:Masked method was used in 87 patientcontrol pairs to determine Lp(a),Total Cholesterin (TC),High Density LiporotienCholesterin (HDLC),Low Density LipoprotienCholesterin (LDLC).Results:①When Lp (a) concentration was used alone to diagnose CHD,the best cut off value was 0.25g/L,the crude agreement was 62.07%,the sensitivity was 60.92%,and the specificity was 63.22%;②The validity of Lp(a) was only better than that of HDLC;③The crude agreement of Lp(a) serialized with one of TC,НDLC,LDLC and LDLC/HDLC in diagnosting CHD was 62.07%～67.24%.Conclusion:The validity of Lp(a)concentration as diagnostic test for CHD is not satisfactory.更多还原