【摘要】 目的 :观察新型血栓素 A2 ( TXA2 )受体拮抗剂达曲班对异丙肾上腺素 ( Iso)诱导的大鼠心肌缺血损伤的保护作用及对心肌四性的影响。方法 :静脉注射 Iso诱发大鼠心肌缺血 ,记录缺血后心功能的变化及心肌细胞病理改变情况。用离体大鼠心房肌进行自律性、收缩性、兴奋性和不应性的研究。结果 :达曲班对缺血后心功能的下降有明显的抑制作用 ,并能明显减轻缺血损伤后心肌细胞坏死和浊肿现象。对离体心房肌能明显延长功能性不应期 ,抑制肾上腺素诱发的自律性 ,而对收缩性和兴奋性无明显影响。 结论 :达曲班有较强的抗心肌缺血作用。更多还原

【Abstract】 Objective:To study the effects of daltroban, a new thromboxane A 2 receptor antagonist on myocardial ischemia injury and isolated myocardium in rats.Methods:Isoprenaline (Iso) was injected by vein to induce myocardial ischemia.The changes of ischemic heart function and pathological state of myocardial cells were observed .The automaticity,contractility,excitability and refractoriness of the isolated atrium muscle of rats were recorded.Results:After daltroban was administrated,the descent of ischemic heart function was markedly inhibited, the necrosis and degeneration of myocardial cells were clearly mitigated, the functional refractory period(FRP)was prolonged and epinnephrine induced automaticity was inhibited obviously.Conclusion:Daltroban has potent anti myocardial ischemic effects.更多还原