【摘要】 目的 :比较低剂量米索前列醇阴道用药配伍口服用药米非司酮中期妊娠引产的临床效果 ,寻求较为合理的给药途径和用药剂量。 方法 :1 1 6例引产的中期妊娠孕妇分为阴道组 ( 60例 )和口服组 ( 56例 )。两组均经米非司酮 ( 1 50 mg)预治疗后 ,于第 3天 1 7时分别给予米索前列醇 2 0 0μg放入阴道后穹隆或口服 ,次晨流产未完成者同途径追加 2 0 0 μg,每隔 3～ 4h重复 1次。 结果 :阴道组和口服组的总引产成功率无显著差异 ( 98.33% ,96.48% ,P>0 .0 5) ,但是米索前列醇 1次用药的成功率两组有显著差异 ( 70 .0 0 % ,1 7.86% ,P<0 .0 1 )。平均用药次数分别为 1 .44次和 3次 ,平均用药量分别为 2 92 μg和 746μg( P<0 .0 1 )。随着孕龄增加 ,用药至流产的时间延长 ,相关系数 ( r) =0 .91 1 6。产后出血量、月经恢复的日期及副作用两组均无明显差异。 结论 :低剂量阴道用米索前列醇配伍米非司酮用于中期妊娠引产较口服用药具有效果好、安全、剂量小、用药次数少的优点 ,是较为理想的用药途径。更多还原

【Abstract】 Objective:To compare the effectiveness of vaginal with oral Misoprostol in the termination of second trimester pregnancy after pretreatment with Mifepristone and to search for a more effective administration route.Methods:116 women asking for termination of second trimester pregnancy were randomized into two groups:1)the vaginal group (n=60)and 2)the oral group (n=56).All woen received Mifepristone (150mg) in the first three days.At 5pm of the third day,they were given Misoprostol (200μg) either vaginally or orally.The next morning,if the abortion was not effected,additional doses were given by the same route every3 4 hours.Results: There were no significant differences in the percentage of women aborting with in 48 hours after the first dosage of Misoprostol was used (98.33% vs 96.48% P>0 05),but the percentage of women aborting within 12 hours in group 1 was significantly higher than that in group 2(70% vs 17.86% P<0 01).The average doses of Misoprostol in group 1 was 1.44,and in the oral group 3.The mean amount of the drug given group 1 was remarkably less than that in group 2 (292μg vs 746μg,P<0 01).The interval from the first dose of Misoprostaol to abortion was prolonged with the increase of gestational age (r)=0.9116, but there were no significant differences between the 2 groups in the amount of postabortion hemorrhage,the instances of side effects and the days from termination of pregnancy to the first menstruation .Conclusion:Being more effective,safer and requiring smaller dosage ,Misoprostol used vaginally had more advantages in the termination of second trimester pregnancy than it was used orally,and may be a more ideal route for the administration of the drug.更多还原