【摘要】 方酸经酯化后与手性氨基醇反应 ,继而与脂肪胺作用合成了六个新型手性方酰氨基醇配体 .研究了它们经原位制备成手性口恶唑硼烷后 ,在不对称催化氢化还原前手性芳酮中的性能 ,得到手性仲醇的对映体过量 (ee)值为 30 %～ 76 % .这些新化合物的结构已被IR ,1HNMR ,MS及元素分析所证实 .更多还原

【Abstract】 Six new chiral squaric acid amidoalcohols were synthesized by the reaction of alkyl amines with 3 butoxy [(1’R,2’S) (2’ hydroxy 1’,2’ diphenylethyl)amino] 3 cyclobutene 1,2 dione, which was prepared by the reaction of (1S,2R) 2 amino 1,2 diphenylalcohol with dibutyl squarate. The in situ formed chiral oxazaborolidines have been used in the enantioselective borane reduction of prochiral ketones afford the alcohol products in a range 30%～75% enantiomeric excesses. All of the new compounds were confirmed by IR, 1HNMR,MS and element analysis.更多还原