【摘要】 观察补肾益智方 (蛇床子、枸杞子、女贞子、人参等组成 )对老年性痴呆 (又称阿尔茨海默病 ,Alzheimer’sdisease ,AD)模型大鼠突触传递长时程增强现象 (long_termpotentiation ,LTP)的影响 ,旨在探讨该方治疗AD作用的神经生物学机制。应用D -半乳糖致亚急性衰老合并Meynert基底核损毁建立AD模型大鼠 ,用补肾益智方对AD大鼠灌胃治疗 4周 ,采用电生理学方法 ,检测大鼠海马齿状回强直刺激诱发的LTP的变化。结果表明 :强直刺激后 ,各组间兴奋性突触后电位增强差异不明显 (P >0 .0 5) ,补肾益智方高、低剂量组群体峰电位幅度增强较模型组明显提高 (P <0 .0 1或P <0 .0 0 1)。提示补肾益智方对AD大鼠齿状回LTP具有改善作用更多还原

【Abstract】 To explore the effects of Bushen Yizhi Decoction(BYD)on the hippocampal long_term potentiation (LTP) in rat model with Alzheimer’s disease(AD),AD rat model was established by intraperitoneral injection of D_galactose and ibotenic acid injection into nucleus basalis of Meynert.Electrophysiological method was used to assess the changes of long_term potentiation of dentate gyrus.BYD groups were treated with gastric infusion of BYD for 4 weeks.The results showed that the differences of potentiation of excited postsynaptic potentials(EPSPs)were not significant among the five groups (P> 0.05 ),and potentiation of population spike(PS)amplitude in BYD groups were significantly different from AD model group.It is suggested that BYD exerts an effect in improving hippocampal LTP in rat model of AD.更多还原