【摘要】 目的刚地弓行虫可以通过胎盘屏障而形成垂直传播,并可引起先天性弓形虫病,早期诊断难并常常会错过早期治疗的机会。本文对PCR和IHA两种诊断方法进行了比较,并采用了磺胺嘧啶和螺旋霉素进行了治疗。方法于1993—1996年间,对296例新生儿静脉血样采用PCR和IHA方法进行了检测。结果 PCR法优于IHA法(P<0.05);以磺胺嘧啶和螺旋霉素治疗的17例患儿全部治愈,而且其生长发育均正常。结论 PCR方法显示出了特异性高、敏感性强并可应用于早期诊断,以预防新生儿死亡和后遗症的发生。各种不同表现的先天性弓形虫病是可以被发现的,而且采用磺胺嘧啶和螺旋霉素可以治愈。更多还原

【Abstract】 Objective Toxoplasma gondii can pass the placental barries to form vertical transmission and causes a congenital toxoplasomosis. The early diagnosis is difficult and the opportunity of early treatment is often missed. In the present paper, a comparison between PCR and IHA technique and the treatment method using sulfadiazinum and spiramycin were made. Methods In 1993-1996, in 296 vein blood samples from newborns examined using PCR and IHA techniques. 17 cases of congenital toxoplasmosis were treated for one year. Results The PCR technique was better than the IHA (P<0.05). 17 cases treated with sulfadiazinum and spiramycin were cured and their growth and development were normal. Conclusion The PCR technique showed high specific and high sensitive and can be applied for the early diagnonsis in order to prevent newborn death and occurrence of sequelae. Different manifestations of congenital toxoplasmosis have been found and can be cured using sulfadiazinum and spiramycin.更多还原