【摘要】 目的：研究增殖细胞核抗原（以下简称PCNA）及癌基因在不同类型肺癌中的表达，探索PCNA，癌基因同肺癌的关系及对临床的意义。方法：用免疫组化S－P法。结果：PCNA、C－erbB－2和P21在不同类型的肺癌中均呈过量表达，三者的阳性细胞同肺癌的类型无关，但同肺癌的发生、发展有着密切的关系。结论二、C－erbB－2和P21的过量表达说明肺癌细胞增殖活性较高，癌基因已有突变和活化，导致肺癌的发生和转移。检测PCNA和癌基因更有助于了解肺癌的生物学村为及预测病人的预后。更多还原

【Abstract】 Objective: To detective the expression of proliferating cell nuclear antigen(PCNA)and oncogenes in various tyges of lung carcinoma, To investigate the relations between PCNA(oncogenes) and lung carci noma and its clinical significance Method: immunohistochemistry (S - P ). Results: The expression of PCN A, C erbB - 2 and P21 are all over expression. There is no relationship between their Positive cells and the types of lungcarnoma. But their positive cells are related closely with the generation and development of lung carcinoma. Conclusion: The over expression of PCNA, C - erbB - 2 and P21 in lung carnoma suggested that there is more proliferative activity in lung carcinoma. Oncogenes has mutated and activated. And the mutation and activation ofoncogenes lead to the g6neration and metastasis of tumor. To detecfive PCNA and oncogenes is significant. It ishelpful to understand the biologicai behavior of lung carcinoma. It can also forecast the patien’s prognpsis.更多还原