【摘要】 目的 :探讨nm2 3和ras基因在骨巨细胞瘤 (GCT)的表达及与GCT病理分级和复发的关系。方法 :应用SP免疫组织化学方法检测nm2 3和ras在 52例GCT (GCT按Jaffe分级 :Ⅰ级 15例、Ⅱ级2 5例、Ⅲ级 12例 )中的表达。结果 :2 1例nm2 3表达阳性 ,阳性率 4 0 .4 % ,7例ras表达呈阳性 ,阳性率13.5%。其阳性表达与病理分级均无显著相关性 (P >0 .0 5)。nm2 3和ras在复发和无复发的病例中 ,阳性表达率分别为 6 9.2 %、30 .8%和 2 3.1%、10 .3%。nm2 3过表达与GCT复发有高度相关性 (P <0 0 5)。而ras基因表达无相关性。结论 :nm2 3和ras表达均与GCT病理分级无关。nm2 3表达与肿瘤复发有关 ,而ras表达与复发未见相关性更多还原

【Abstract】 Objective: To study the expression of the nm23 and ras protein in human giant cell tumor of bone and their relationship with pathological types and recurrence.Methods: Applying SP immunohistochemic method to detelt expression of these proteins in the giant cell tumor of bone.Results: of 52 tumors,21 had abnormally high levels nm23 protein,7 expressed ras protein.Their positive expression had no significant correlation with pathological grades.There was a striking statistically significant correlation between the overexpression of nm23 protein and recurrence ( P <0 05). Conclusions There was a statistically significant correlation between the expression of nm23 protein in the giant cell tumor of bone and recurrence.( P <0 05).However,there was no statistically relationship between the expression of nm23 and ras protein in the giant cell tumor of bone and pathological grades.更多还原