【摘要】 目的 :探讨干扰素 (IFN)联合顺铂 (DDP)加 5-氟脲嘧啶 ( 5 FU)腹腔化疗治疗卵巢癌合并腹水的临床疗效。方法 :将 36例卵巢癌合并腹水患者随机分为两组 ,先将腹水尽量放尽。PF组 :腹腔灌注DDP 80mg +5 FU 10 0 0mg +生理盐水 150 0ml ,合并IFN组在PF组基础上加用α 2b IFN 60 0万IU ,两组均每周用药 1次 ,共 3次。治疗 3个疗程后 7～ 14d评定疗效 ,并对两组腹腔化疗后行手术治疗的标本进行病理形态观察。结果 :合并IFN组腹水消退率为 70 % ,肿瘤消退率为 30 % ,均高于PF组 ,差异均有显著性 (分别为P =0 .0 4 2 ;P =0 .0 2 0 ) ;镜检其癌细胞Ⅲ +Ⅳ级反应率明显高于PF组 (P =0 .0 2 8)。结论 :IFN联合PF腹腔化疗治疗卵巢癌合并腹水安全有效 ,值得推广更多还原

【Abstract】 Objective:To investigate the effects of the combination introperitoneal interferon alpha 2b(α 2b IFN) and cisplation (DDP) plus 5 FU in ovarian cancer ascites. Methods:36 ovarian cancer ascites were randomized into two groups which drained out ascites as much as possible at first, then received introperitoneal administration once every 1 week altogether three courses.The PF group: DDP 80 mg and 5 FU 1 000 mg which were dissolved in 1 500 ml of natural sodium, the combination IFN group: combination IFN 6×10 6 IU in the base of PF. To evaluate the effects and observation postoperative sample pathology features’changing after three courses.Results: The ascites diminishing rate was 70% and the mass diminishing rate was 30% in the combination IFN group.Both were greater than the PF group.There were significant difference(respectively P=0 042;P=0 020 ).Cancer cells reaction rate in Ⅲ plus Ⅳ grade was greatly increased than PF groud ( P=0 028 ).Conclusion:Combination intraperitoneal IFN and PF in ovarian cancer ascites is effective,safe and promising therapy.更多还原