【摘要】 目的 :研究晚期胰腺癌病人抗凝、纤溶功能的变化 ,并探讨其临床意义。方法 :以AT ⅢA %、AT ⅢAg、PC :A反映抗凝功能 ,PLg、tpA :A、PAI :A、FDP等 4项指标反映纤溶功能 ,并与正常人群对照。结果 :在晚期胰腺癌组 ,AT ⅢA %降低 (P <0 0 1) ,而AT ⅢAg、PC :A升高 (P <0 0 1)。PLg、tpA :A、PAI :A均降低 (P <0 0 1) ,而FDP明显升高 (P <0 0 0 1)。结论 :晚期胰腺癌患者存在明显的抗凝、纤溶异常 ,原因与胰腺癌本身有关 ,如不加以正确处理 ,将使病情恶化更多还原

【Abstract】 Objective:To study the function change of the plasma anticoagulantion and fibrinolysis systems in carcinoma of the pancreas.Methods:22 patients with carcinoma of pancreas were studied.The parameters of plasma anticoagulantion including AT ⅢA%,AT ⅢAg,PC:A, the parameters for plasma fibrinolysis are PLg,tPA:A,PAI:A and FDP. All these parameters were expressed as ±s . and students t test was used when compared with normal people.Results:It was found that the level of .AT ⅢA% was lower than normal(P<0 01),but AT ⅢAg,PC:A were all higher than normal(P<0 01).Except for FDP.the level of Plg,tpA:A and PAI:A were all loewr than normal(P<0 01),but FDP was higher than normal(P<0 001).Conclusions:In patients with carcinoma of pancreas, there are obvious abnormal in plasma anticoagulantion and fibrinolysis systems.Most patients were in prothrombin status. This prothrombin status is the complication of carcinoma of pancreas itself,and can aggravate if correct therapy is not followed.更多还原