【摘要】 目的 :观察去甲长春碱 (Navelbine ,NVB)加顺铂 (Cisplatin ,DDP)治疗非小细胞肺癌 (nonsmallcelllungcancer ,NSCLC)的疗效和安全性。方法 :治疗NSCLC 2 6例 ,采用NVB 30mg/m2 静脉推入 ,第1、8天 ;DDP 2 0mg静脉点滴 ,连用 5天。结果 :部分缓解 (PR) 10例 ,稳定 (SD) 8例 ,进展 (PD) 4例 ,总有效率 4 5 4 %。NVB的主要毒性反应为骨髓抑制 ,白细胞下降占 61 5% ,其中 3、4度占 34 6%。其他毒性反应有恶心呕吐 ( 53 9% ) ,局部静脉炎 ( 36 7% )。结论 :NVB加DDP联合治疗NSCLC有一定的疗效 ,对既往化疗无效的患者可作为挽救化疗方案使用。毒性主要为骨髓抑制 ,可用G CSF治疗更多还原

【Abstract】 Objective:To evaluation the effect and safety of combination chemotherapy with navelbine (NVB) plus cisplatin(DDP) in the treatment of nonsmall cell lung cancer(NSCLC).Methods:26 patients with NSCLC were enrolled in this study.NVB was administered at a dose of 30mg/m2 on day 1 and day 8,DDP 20mg from day 1 to day 5.Results:Partial response was observed in 10 patients,overall response rate is 454%. The main toxicity was neutropenia which was seen in 615% of the patients(346% in grade 3 and 4).Vomitting was observed in 539% of the patients.The local venous toxicity 367%.Conclusions:NVB plus DDP yields a certain response with acceptable toxicity in our study.This combination should be considered as a relevant regiment in NSCLC.更多还原