【摘要】 为了对照性研究应用西地那非 (Sildenafil,ViagraTM)和育亨宾治疗男子阴茎勃起功能障碍 (ED)的效果。把 2 34例ED(器质性 41 % ,心理性 46 % ,混合性 1 3% )随机双盲分为两组 ,西地那非组 1 34例 ,用西地那非 5 0～ 1 0 0mg ,性交前 6 0分钟口服 ,每天一次 ,连服 2天后 ,改为 2～ 3天服一次 ,连用 4～ 1 2周。育亨宾组 1 0 0例 ,用育亨宾 (Yohimbine) 5 .4～ 1 0 .8mg ,每天服 3次 ,连用 4～ 1 2周。结果表明西地那非组口服西地那非 5 0～ 1 0 0mg后 ,有效率为 6 1 .1 9～ 79.1 0 % ,育亨宾组的有效率为 40 % ,两组疗效经统计学处理有显著性差别 (P <0 .0 1 )。本资料显示西地那非治疗各种原因的ED是安全有效的 ,副作用少而轻 ,可以长期治疗 ,相比之下育亨宾的效果较差更多还原

【Abstract】 In order to investigate the efficacy of sildenafil (Viagra TM ) and Yohimbine for male erectile dysfunction (ED). This meta analysis of 234 cases with ED (organic 41%, Psychogenic 46%,mixed 13%) were randomly assigned into two groups by double blind method. Patients in sildenafil group were treated with sildenafil 50mg to 100mg once daily approximately 1 hour before sexual activity over 4 to 12 weeks. Patients in control group were given 5.4 mg to 10.8mg of yohimbine thrice daily for 4 to 12 weeks. After 4 to 12 weeks, the effective rates of 50mg and 100mg sildenafil group were 61.19% and 79.10% respectively. While the reponse rates of the control group were 26.66% and 40%. ( P <0.01). The results indiacte that silenafil, at doses of 50mg and 100mg is effective in men with ED.更多还原