【摘要】 目的 :研究丙氨瑞林对子宫内膜癌直接作用的可能性。方法 :以不同浓度丙氨瑞林 (浓度为 10 - 9～ 10 - 5 mol/ L)与人子宫内膜癌细胞株 HEC-1A(中分化子宫内膜腺癌 )一起进行培养 72 h,观察各浓度下癌细胞的抑制情况。结果 :当丙氨瑞林浓度为10 - 9mol/ L时 ,癌细胞生长即受到抑制 ,抑制率为 3 7.0± 2 6.2 %;随着丙氨瑞林浓度的增大 ,抑制率渐高。结论 :丙氨瑞林在体外对HEC-1A细胞可能有直接抑制作用 ,且呈剂量依赖关系。更多还原

【Abstract】 Objective:To evaluate the possible direct effect of Alarelin on endometrial carcinoma.Methods:Human endometrial carcinoma cell line HEC-1A cells was chosen to assay the inhibitory rate when given a range of concentrations Alarelin (from 10 -9 mol/L to 10 -5 mol/L) and co-cultured for 72 hours.Results:The growth of HEC-1A cells was inhibited when the lowest Alarelin concentration 10 -9 mol/L was given,the inhibitory rate was 37.0±26.2%. The inhibitory rate increased with the rising of Alarelin concentrations.Conclusion:Alarelin might have direct inhibitory response on HEC-1A cells in vitro and the effect was dose-dependent. [更多还原