【摘要】 研究诺迪康对大鼠实验性心肌缺血的影响。结扎Wistar大鼠左冠状动脉造成急性心肌缺血 ,在结扎冠脉 15min后经十二指肠给药 ,记录给药前及给药后不同时间胸前多导联心电图 (9点 ) ,以 ST和NST来反映心肌缺血程度和范围 ;于结扎冠脉后 180min ,摘取心脏 ,用N -BT染色确定心肌梗塞面积。与空白对照相比 ,诺迪康 1 0 0g/kg、0 5 0g/kg在 30min时使 ST分别下降 2 9 92 %、2 6 81% (P <0 0 1) ;使NST分别降低 14 47%、8 82 % (P <0 0 1)持续 180min ,使梗塞面积由对照组的 15 14%分别降到 8 15 %、13 38% (P <0 0 1,P <0 0 5 )。诺迪康可降低大鼠实验性心肌缺血程度和缺血范围 ,减少梗塞面积。更多还原

【Abstract】 To study the effects of Nuo Di Kang on experimental myocardial ischemia schema in rats acute myocardial ischemia model was performed with left coronary artery descending(LAD)occlusion in Wistar rat heart.ST and NST of electrocardiograph(ECG)were used to evaluate myocardial ischemia extent and region respectively Myocardial infarction area was determined by N BT dying. after LAD occlusin 1.00,0.50 g/kg Ruo Di Kang could reduce ST 29.92%,26.81% at 30min;also reduce NST 14.47%,8.82% lasting to 180Min,respectively.(P<0.01,compared with control group).Myocardial infarction district was decreased from 15.14% to 8.15,13.38%(P<0.01,P<0.05),respectively. Nuo Di Kang could reduce myocardial ischemia extent and myocardial infarction area in experimental ischemia rat hearts.更多还原