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甘草残渣中多糖GPS抗肿瘤作用的研究

RESEARCH ON THE BIOLOGICAL ACTIVITIES OF A POLYSACCHARIDE EXTRACTED FROM RESIDUE OF GLYCYRRHIZA URALENSIS FISCH

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【作者】 王岳五张海波吕杰史玉荣何敏王双石丁友舫

【Author】 BHDWG1*2,WK42W]Wang Yuewu, Zhang Haibo, Lü Jie(Department of Microbiology, Nankai University, Tianjin,300071) Shi Yurong, He MinWang Shuangshi, Ding Youfang (Tianjin Institute of Tumor, Tianjin,300070) (Institute of White Agric

【机构】 南开大学微生物学系!天津300071天津市肿瘤研究所!天津300070北京市白色农业研究所!北京102100

【摘要】 自甘草残渣中分离一种水溶性葡聚糖 GPS,急性毒性实验证明其属无毒物质 .通过体内抑瘤实验表明 ,GPS对小鼠肉瘤 S-1 80及艾氏腹水移植瘤皆有明显抑制作用 ,其抑制率分别高于 80 %和 30 % .同时对多糖的药理作用也略加介绍

【Abstract】 A polysaccharide (GPS) was isolated and purified from residues of Glycyrrhiza uralensis Fisch, which was identified to be a glucan. Acute toxicity test showed that GPS was non toxic. Taking tumor bearing mice as animal models, result of experiments showed that GPS had strong inhibition effects on the growth of both sarcoma 180 and EAC, the inhibition rates were higher than 80% and 30% respectwely.

  • 【文献出处】 南开大学学报(自然科学版) ,Journal of Nankai University , 编辑部邮箱 ,2000年04期
  • 【分类号】R285
  • 【被引频次】99
  • 【下载频次】310
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