【摘要】 目的　探讨 Graves病 ( GD)患者外周血可溶性凋亡相关蛋白 Fas( s Fas)的变化特点及其临床意义。方法　采用酶联免疫吸附法检测 47例治疗不同时期 GD病患者和 2 0例正常人外周血血清 s Fas的含量。结果　 1GD患者血清 s Fas含量明显高于正常对照 ( P<0 .0 1) ;与 GD初发组相比 ,GD缓解组和临床痊愈组患者血清 s Fas逐步降低 ,彼此之间存在显著性差异 ( P<0 .0 1) ;2血清 s Fas与 GD患者促甲状腺素受体抗体 ( TRAb)水平呈显著正相关 ( r=0 .41,P<0 .0 5 ) ,而与患者年龄、甲状腺激素 ( FT3、FT4)、促甲状腺激素 ( TSH)、甲状腺球蛋白抗体 ( TGAb)、甲状腺过氧化物酶抗体 ( TPOAb)之间无明显相关关系。结论　 GD患者体内存在 s Fas的异常表达 ,由此加重甲状腺肿大和局部免疫功能的紊乱 ,在 GD的发生发展中发挥重要作用更多还原

【Abstract】 Objective To investigate the serum concentration of soluble Fas (sFas) in pateients with Graves′ disease (GD). Methods Serum levels of sFas were determined by enzymelinked immunosorbent assay in 47 patients with GD. Results The serum concerntration of sFas was significantly increased in GD patients compared with agematched control subjects(5.1±0.2 vs 2.1±0.5 P<0.01). The level of serum sFas was decreased after the medication of antithyroid drugs for 8 to 16 weeks and significantly lower in patients who were euthyroid more than 1 year. The concentration of serum sFas was positively correlated with the titers of antithyrotropin (TSH) receptor antibody, but not with other parameters (free riiodothyronine[FT3], free thyroxine[FT4],TSH, antithyroglobulin antibody titers and antiperoxidase antibody titers).Conclusion The increased serum levels of sFas in GD can aggravate the formation of goiter and local immune disturbance. It suggests that sFas may play an important role in the pathogenesis of GD.更多还原